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X-ray crystallography and multi-dimensional NMR are now the main experimental approaches to determination of threedimensional structure of biomacromolecules. These techniques are independent of each other in both preparation of sample and the physical parameter used to calculate struc-

Using these bags is easy you just pop the component inside the bag. You can, if you want, fold the end over and even add a staple to it for extra security (it doesn t affect the ESD properties of the bag at all).

Figure 25-4: Use the Geographic Location dialog box to specify the latitude and longitude for a specific location.

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The stomach is richly innervated with mechanoreceptors that respond to gastric lling and that signal to the brain via both vagal and spinal afferents. The effects of gastric mechanoreceptors on eating have been elegantly analysed in rats carrying both a gastric cannula (to drain the stomach), and a cuff around the pylorus that can be in ated to prevent gastric emptying. These studies found that meal size is signi cantly increased when the stomach is continually drained, and signi cantly decreased when the stomach is distended with uid against a closed pylorus; the latter decreases were proportional to the volume of the uid infused and occurred whether nutrient or nonnutrient uids were used (Eisen et al., 2001; Kaplan and Moran, 2004; Phillips and Powley, 1996). Thus, gastric distension can contribute to the control of eating, but this effect is normally rather small: the stomach has to be markedly distended for eating to be inhibited. As described below, however, it is possible that this mechanism may be enhanced by signals generated by food entering the gut beyond the stomach.

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Movement of a particle across a stationary surface is inhibited by friction. The effect of this is to slow the movement of the particle. If the particle is present as a uid (i.e. a liquid or gas), this friction gives rise to the phenomenon called viscosity. The molecular effects underlying viscosity depend partly on intermolecular interactions within the solution (e.g. van der Waals, hydrogen bonds, electrostatic interactions) and partly on the overall size and shape of solvent and solute molecules. Liquids are far more viscous than gases since intermolecular interactions are more common in the liquid than the gas phase. In the experimental situation described in Figure 7.1, ow of a liquid between two parallel plates separated by a distance, y, is shown. In 7.1(a), one of the plates is moving at a velocity, v, while the other plate is stationary and in 7.1(b) the liquid is moving with velocity, v, but both plates are stationary. Situations very similar to these could be expected to arise in many electrophoretic and chromatographic experimental formats using water as the main solvent. Since the velocity vectors of successive layers of water near to stationary plates would trace a parabolic shape, this phenomenon is called parabolic ow. Newton observed that the layer of liquid immediately adjacent to the moving plate in 7.1(a) would have a velocity very close to v while that adjacent to the stationary plate would have a velocity close to zero. Thus, a velocity gradient

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